' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 14 Reviews
8.6
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
7
Vitamin D's role in heart health
The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.
Direct focus on heart disease
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
Read More
8
Vitamin D's impact on heart hypertrophy
Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy.
Significant relevance in heart disease
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
9
Zinc benefits heart health post-cisplatin
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Significant relevance to heart protection
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
Read More
Most Useful Reviews
9.5
Angina symptoms reduce
Heart throbbing and painful leg cramps have disappeared. After years of unexplained angina symptoms, this combination of minerals proved effective for me, essential for addressing heart disease.
Read More
9.5
Improved heart symptoms
Excellent composition! I take one capsule instead of three for magnesium, calcium, and zinc. It's effective; my hair and nails are stronger, and it alleviated my heart disease symptoms over a month. My husband had leg cramps that improved after a week on it. Great value, especially with a discount!
Read More
8.8
Joint pain relief
This combination is perfect for me. With the vitamin D formula, I’ve noticed improvement in joint pain and overall energy levels, which is beneficial in addressing heart disease and its related symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
9
Mitochondrial calcium uptake and heart
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.
MCU's role in heart health
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
9
Zinc's role in cardiac protection
ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts.
Study emphasizes combined treatment effects
We explored the fascinating relationship between heart health, atrial natriuretic peptide (ANP), and zinc (Zn) in the context of ischemia/reperfusion (I/R) injury, a condition that occurs when blood supply returns to the heart after a period of being blocked. Our research utilized a range of models, including isolated heart experiments in rats and ANP knockout mice, along with clinical investigations involving plasma samples from 216 patients suffering from ischemia-related diseases.
During our experiments, we observed that levels of ANP significantly increased during reperfusion, which, in turn, promoted zinc accumulation in the heart tissue. This uptick in zinc led to protective effects on the heart, primarily by reducing injury during the reperfusion phase. Interestingly, when we applied a zinc chelator, we found that it negated the beneficial impacts of both ANP and zinc, highlighting the crucial role zinc plays in conjunction with ANP.
Furthermore, we discovered that ANP modulates zinc levels by downregulating a specific transporter known as ZnT8 through a pathway called PI3K signaling. While the interplay between ANP and zinc is evident, the study suggests that zinc alone's effectiveness in treating heart conditions cannot be fully isolated due to these combined effects. Overall, our findings point to a complex relationship in heart protection strategies, where both ANP and zinc play essential, interlinked roles.
During our experiments, we observed that levels of ANP significantly increased during reperfusion, which, in turn, promoted zinc accumulation in the heart tissue. This uptick in zinc led to protective effects on the heart, primarily by reducing injury during the reperfusion phase. Interestingly, when we applied a zinc chelator, we found that it negated the beneficial impacts of both ANP and zinc, highlighting the crucial role zinc plays in conjunction with ANP.
Furthermore, we discovered that ANP modulates zinc levels by downregulating a specific transporter known as ZnT8 through a pathway called PI3K signaling. While the interplay between ANP and zinc is evident, the study suggests that zinc alone's effectiveness in treating heart conditions cannot be fully isolated due to these combined effects. Overall, our findings point to a complex relationship in heart protection strategies, where both ANP and zinc play essential, interlinked roles.
Read More
9
Zinc benefits heart health post-cisplatin
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Significant relevance to heart protection
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
Read More
8
Vitamin D3 and SGLT2i synergy explored
Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.
Combined treatment benefits assessed
We conducted a study to explore how vitamin D3, combined with SGLT2 inhibitors, could influence heart health in hypertensive obese patients suffering from obstructive sleep apnea (OSA). This combination therapy was assessed for its effects on various health parameters and the quality of life of the participants.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
Read More
8
Vitamin D's impact on heart hypertrophy
Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy.
Significant relevance in heart disease
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.6
9.5
Angina symptoms reduce
Heart throbbing and painful leg cramps have disappeared. After years of unexplained angina symptoms, this combination of minerals proved effective for me, essential for addressing heart disease.
9.5
Improved heart symptoms
Excellent composition! I take one capsule instead of three for magnesium, calcium, and zinc. It's effective; my hair and nails are stronger, and it alleviated my heart disease symptoms over a month. My husband had leg cramps that improved after a week on it. Great value, especially with a discount!
Read More
8.8
Immune system boost
Excellent! Zinc is essential for human health and boosts the immune system. A review of 18 studies revealed that taking zinc on the first day of cold symptoms can reduce their duration and severity by about one day, contributing positively to managing heart disease.
8.8
Improved sleep quality
I began with the benefits of the minerals in this jar. Calcium strengthens bones, magnesium regulates heart rate, and zinc aids metabolism. After finishing the jar, I noticed better sleep and overall improvements, which may help in dealing with heart disease, and my family is also pleased with the results.
Read More
8.8
Joint pain relief
This combination is perfect for me. With the vitamin D formula, I’ve noticed improvement in joint pain and overall energy levels, which is beneficial in addressing heart disease and its related symptoms.
